Effects of mild hypercapnia on myocardial injury among ST-elevation myocardial infarction patients after out-of-hospital cardiac arrest: a exploratory post-hoc study of the TAME trial

Abstract

Background: Targeting mild hypercapnia reduced myocardial injury in a single-centre cohort of STelevation myocardial infarction (STEMI) patients from the multinational Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. We examined the effect of mild hypercapnia on myocardial injury and outcomes in all acute myocardial infarction (AMI) patients of the TAME trial. Methods: Post-hoc exploratory study of the TAME trial that compared the effect of targeted mild hypercapnia or normocapnia in comatose adults after out-of-hospital cardiac arrest (OHCA). The primary outcome was myocardial injury assessed by peak high-sensitivity cardiac troponin T (hs-cTnT) or tropo..